If this is Exchange 2003, this is a User Setting, 2007 and up it is a Server Setting. In EMC navigate to Remote Domain > bring up the properties of Default > Format of original message sent as an attachment to journal report > Allow auto-repliesīest practice is disabling the Global Settings configuration (as default) once the transition period ends. To check if auto-reply is set follow the steps below. Reminder that you have to make sure that you allow auto-reply as a global setting. Youll see the gear icon at the top-right corner of your inbox. Click New Rule > Check messages when they arrive > Next > Yes to prompt > Have server reply using a specific message > click a specific message in Step 2 window > Next > Next > Finish Click the gear icon and select View all Outlook settings.Once Outlook opens navigate to Tools > Rules and Alerts.

Now on your Workstation create a new outlook profile for the disabled account.Add your account to the list of the accounts that have full permissions.Right click on the disabled account and select Manage Full Access Permissions.Open EMC navigate to Recipient Configuration > Mailbox and highlight the account that you disabled.

If it is the Active Directory-object that is disabled, you can set an out of office reply on their account: (the suggestion below assumes this is Exchange and not O365) Since as Michev is asking for a definition of 'disabled mailbox' the above will not work if the mailbox has been deleted or fully disabled and it is returning 'the email address is no longer valid'

Two things you can do if you've disabled the mailbox you can use Powershell with this cmdlet to set the autoreply 'Set-MailboxAutoRepl圜onfiguration -Identity tony -AutoReplyState Enabled -InternalMessage 'Internal auto-reply message.' -ExternalMessage 'External auto-reply message.''

Setup out of office outlook 365